Epithalon
$49.99
Epithalon (Epitalon) — a synthetic tetrapeptide (Ala-Glu-Asp-Gly) studied for telomerase activation and pineal gland function. 99%+ purity, HPLC verified. 10mg per vial. For research use only.
Description
Epithalon (Epitalon) — Telomerase-Activating Tetrapeptide
Professor Vladimir Khavinson’s research group at the St. Petersburg Institute of Bioregulation and Gerontology published data in 2003 showing epithalon activated telomerase in human somatic cells — the first synthetic peptide demonstrated to do so in a controlled setting. That paper in Bulletin of Experimental Biology and Medicine changed the direction of biogerontology research overnight.
Epithalon is a four-amino acid peptide (Ala-Glu-Asp-Gly) based on the naturally occurring epithalamin extract from the pineal gland. Structurally simple. Mechanistically complex.
Molecular Profile
| Specification | Detail |
|---|---|
| Sequence | Ala-Glu-Asp-Gly |
| Molecular Weight | 390.35 Da |
| CAS Number | 307297-39-8 |
| Purity | ≥99% (HPLC) |
| Form | Lyophilized powder |
| Quantity | 10mg per vial |
| Storage | -20°C lyophilized; 2-8°C reconstituted |
Research Applications
Epithalon’s primary studied mechanism involves activation of telomerase reverse transcriptase (hTERT) — the catalytic subunit responsible for elongating telomeric DNA. Telomere shortening is one of the hallmarks of cellular aging identified by López-Otín et al. (2013, Cell), making epithalon a focal compound in longevity research.
Key published research directions:
- Telomerase activation — Khavinson & Malinin (2005) demonstrated dose-dependent telomerase induction in human fetal fibroblast cultures, extending replicative capacity beyond the Hayflick limit
- Pineal gland function — Research shows epithalon influences melatonin synthesis rhythms, with implications for circadian biology (Anisimov et al., 2001, Mechanisms of Ageing and Development)
- Retinal degeneration models — Khavinson et al. (2002) published data on retinal cell preservation in rodent models exposed to constant illumination stress
- Antioxidant enzyme expression — Multiple studies document upregulation of SOD and glutathione peroxidase in tissue models treated with epithalon
Stability & Handling
Epithalon is remarkably stable as a lyophilized powder — the short chain length makes it resistant to degradation. Store at -20°C for maximum shelf life. Reconstitute with bacteriostatic water. Once in solution, refrigerate and use within 30 days.
Why PreWorkout Formula
Third-party HPLC and mass spec on every lot. No proprietary blends, no unlisted excipients. What’s on the label is what’s in the vial.
Related Products
Researchers exploring longevity and cellular aging pathways often investigate these alongside epithalon:
- Sermorelin — GH-axis and age-related endocrine research
- Thymosin Alpha 1 — immune modulation and thymic peptide research
- Selank — neuropeptide and immune function studies
- Semax — neurotrophic factor expression research
Frequently Asked Questions
What does epithalon do in research models?
Epithalon is studied primarily for its ability to activate telomerase reverse transcriptase (hTERT), which elongates telomeric DNA sequences. Secondary research areas include melatonin synthesis regulation and antioxidant enzyme expression.
Is epithalon the same as epithalamin?
No. Epithalamin is a crude extract from bovine pineal glands containing multiple bioactive fractions. Epithalon is the specific synthetic tetrapeptide (Ala-Glu-Asp-Gly) identified as the active component responsible for telomerase activation.
What purity is this epithalon?
≥99% purity confirmed through HPLC analysis. Batch-specific certificates of analysis are available.
How is epithalon stored properly?
Lyophilized epithalon stores at -20°C. Its short peptide chain gives it excellent stability. After reconstitution, keep refrigerated at 2-8°C.
What research has been published on epithalon and telomeres?
Khavinson’s group published extensively between 2000-2010 demonstrating telomerase activation in human somatic cell cultures. Their 2003 paper in Bulletin of Experimental Biology and Medicine is the most cited, showing cells treated with epithalon exceeded normal replicative limits by 10+ passages.
Does epithalon affect melatonin production in research?
Yes. Anisimov et al. documented restored nocturnal melatonin peaks in aged rodent models, suggesting epithalon influences pinealocyte function and circadian melatonin rhythms.
What is the molecular weight of epithalon?
390.35 Daltons. It’s one of the smallest bioactive peptides in active research — just four amino acids.
Where can I buy epithalon for research?
PreWorkout Formula stocks HPLC-verified epithalon at 99%+ purity with fast shipping. All sales are restricted to qualified research use.
This product is intended for laboratory and research use only. Not for human consumption. By purchasing, you agree to use this product solely for legitimate research purposes.
