Selank
$39.99
Selank — a synthetic heptapeptide derived from the immunomodulatory peptide tuftsin, with added Pro-Gly-Pro stabilizing sequence. Dual anxiolytic and immune research applications. 99%+ purity, HPLC verified. 5mg per vial. For research use only.
Description
Selank — Tuftsin-Derived Anxiolytic & Immune Research Peptide
Researchers at the Institute of Molecular Genetics (Russian Academy of Sciences) spent over a decade developing Selank before it earned regulatory approval in Russia in 2009. The design principle was straightforward: take tuftsin — an endogenous tetrapeptide with known immune activity — and stabilize it with a Pro-Gly-Pro C-terminal extension to resist enzymatic degradation. The result was a heptapeptide with a half-life roughly 4x longer than its parent compound and a dual mechanism spanning both immune and central nervous system pathways.
That dual action is what makes Selank unusual. Most peptides fit neatly into one research category. Selank doesn’t.
Molecular Profile
| Specification | Detail |
|---|---|
| Sequence | Thr-Lys-Pro-Arg-Pro-Gly-Pro (tuftsin + PGP) |
| Molecular Weight | 751.9 Da |
| CAS Number | 129954-34-3 |
| Purity | ≥99% (HPLC) |
| Form | Lyophilized powder |
| Quantity | 5mg per vial |
| Storage | -20°C lyophilized; 2-8°C reconstituted |
Research Applications
Selank’s anxiolytic research profile centers on GABAergic modulation. Meshavkin et al. (2006, Bulletin of Experimental Biology and Medicine) demonstrated that Selank influenced the expression of 36 genes in hippocampal tissue, including GABA transporter genes GAT-1 and GAT-3. Separate work confirmed allosteric effects on GABA-A receptor subtypes — a mechanism distinct from benzodiazepine binding.
Published research directions include:
- Anxiety-related behavior models — Seredenin & Kozlovskii (2012) showed Selank produced anxiolytic effects in elevated plus maze and open field tests comparable to reference compounds, without sedation or motor impairment
- BDNF expression — Selank administration increased brain-derived neurotrophic factor (BDNF) mRNA in rodent hippocampal tissue, documented by Inozemtseva et al. (2008)
- Immune modulation via tuftsin pathway — The parent peptide tuftsin is a natural activator of phagocytosis and NK cell function. Selank retains this activity while adding CNS penetration via the stabilizing PGP tail
- Gene expression profiling — Genome-wide studies show Selank modulates clusters of genes involved in inflammatory response, neurotransmitter metabolism, and oxidative stress pathways simultaneously
- Enkephalin metabolism — Research indicates Selank inhibits enkephalin-degrading enzymes, potentially prolonging endogenous opioid peptide activity
Stability & Reconstitution
The Pro-Gly-Pro tail gives Selank significantly better protease resistance than native tuftsin. Lyophilized storage at -20°C. Reconstitute with bacteriostatic water. Solution stable at 2-8°C for up to 21 days.
Quality Standards
Third-party HPLC purity testing and mass spectrometry identity confirmation on every production lot. No fillers or bulking agents.
Related Products
Researchers working with neuropeptides and immune-modulating compounds often study these alongside Selank:
- Semax — ACTH-derived neuropeptide, often studied in parallel with Selank for comparative neurotrophic research
- Thymosin Alpha 1 — TLR-mediated immune modulation peptide
- Epithalon — telomerase activation and longevity research
- Sermorelin — GH-axis and neuroendocrine studies
Frequently Asked Questions
What is Selank derived from?
Selank is a synthetic analog of tuftsin (Thr-Lys-Pro-Arg), a naturally occurring immunomodulatory tetrapeptide. The addition of a Pro-Gly-Pro sequence extends its half-life and enables CNS research applications beyond tuftsin’s native immune functions.
How does Selank affect GABA signaling in research?
Published research shows Selank modulates GABA transporter expression (GAT-1, GAT-3) and exhibits allosteric activity at GABA-A receptor subtypes. This mechanism is structurally and pharmacologically distinct from benzodiazepine-class binding.
What is the relationship between Selank and Semax?
Both were developed at the Institute of Molecular Genetics in Moscow. Selank is tuftsin-derived with anxiolytic and immune research applications. Semax is ACTH(4-10)-derived with nootropic and neurotrophic research applications. Different parent peptides, different primary mechanisms, but overlapping interest in neuroprotection research.
Does Selank cross the blood-brain barrier in research models?
The Pro-Gly-Pro stabilizing tail enhances CNS bioavailability compared to native tuftsin. Intranasal administration models have demonstrated central effects, suggesting effective BBB penetration in research settings.
What is the purity of this Selank?
≥99% confirmed via third-party HPLC analysis. Certificates of analysis available per batch.
How does Selank affect BDNF in research?
Inozemtseva et al. (2008) documented increased BDNF mRNA expression in hippocampal tissue following Selank administration. BDNF is a key neurotrophin involved in synaptic plasticity and neuronal survival research.
What makes Selank different from other anxiolytic research compounds?
Two things: the dual immune/CNS mechanism (most anxiolytic compounds lack meaningful immune activity), and the absence of sedative or motor-impairing effects observed in published behavioral studies. That combination is rare.
Where can I buy Selank for research?
PreWorkout Formula offers 99%+ purity Selank with HPLC verification and fast shipping. All products are for qualified research use only.
This product is intended for laboratory and research use only. Not for human consumption. By purchasing, you agree to use this product solely for legitimate research purposes.
