Sermorelin
$49.00
Sermorelin acetate — a 29-amino acid GRF(1-29) analog that targets the GHRH receptor with high specificity. 99%+ purity, HPLC verified. 5mg per vial. For research use only.
Description
Sermorelin Acetate — GRF(1-29) Research Peptide
A 1990 study published in The Journal of Clinical Endocrinology & Metabolism demonstrated that sermorelin acetate stimulated pulsatile GH secretion in a dose-dependent manner across all test subjects. That single finding launched three decades of follow-up research — and we still haven’t exhausted what this peptide can do.
Sermorelin is the truncated analog of growth hormone-releasing hormone (GHRH), consisting of the first 29 amino acids of the 44-amino acid native peptide. Those 29 residues contain the full biological activity. Nothing wasted.
Molecular Profile
| Specification | Detail |
|---|---|
| Sequence | GRF(1-29)NH₂ |
| Molecular Weight | 3,357.9 Da |
| CAS Number | 86168-78-7 |
| Purity | ≥99% (HPLC) |
| Form | Lyophilized powder |
| Quantity | 5mg per vial |
| Storage | -20°C lyophilized; 2-8°C reconstituted |
Research Applications
Sermorelin’s primary mechanism targets the GHRH receptor (GHRHR) on anterior pituitary somatotroph cells. Binding triggers the cAMP/PKA signaling cascade, which drives both GH synthesis and secretion. Unlike synthetic GH analogs, sermorelin preserves the hypothalamic-pituitary feedback loop — a critical distinction for longitudinal research protocols.
Published research areas include:
- Age-related GH decline — Vittone et al. (1997, Journal of Gerontology) showed sermorelin restored GH pulsatility in older subjects to patterns resembling younger controls
- Sleep architecture — Steiger et al. (1992, Psychoneuroendocrinology) documented increased slow-wave sleep duration following GHRH administration
- Body composition modeling — Multiple studies have examined lean mass and adipose tissue ratios under controlled sermorelin protocols
- Cardiac tissue research — Bhatt et al. (2005) identified cardioprotective signaling through GHRH receptor activation in cardiac cell models
Handling & Reconstitution
Reconstitute with bacteriostatic water at a standard concentration. Lyophilized sermorelin is stable at room temperature during shipping but should be stored at -20°C long-term. Once reconstituted, store at 2-8°C and use within 21 days.
Why Researchers Choose PreWorkout Formula
Every batch ships with third-party HPLC and mass spectrometry verification. No fillers. No ambiguous sourcing. Certificate of analysis available on request.
Related Products
Researchers studying GH-axis peptides often pair sermorelin with complementary compounds:
- Epithalon — telomerase activation research
- Semax — neuroprotective signaling studies
- Selank — anxiolytic and immune modulation research
- Thymosin Alpha 1 — immune regulation peptide
Frequently Asked Questions
What is sermorelin acetate used for in research?
Sermorelin is used to study GHRH receptor signaling, pulsatile growth hormone secretion, and downstream effects on IGF-1 pathways. Research models include age-related endocrine decline, sleep physiology, and body composition.
How does sermorelin differ from synthetic HGH in research settings?
Sermorelin stimulates endogenous GH release through the natural GHRH receptor pathway. Synthetic HGH bypasses the pituitary entirely. This makes sermorelin more relevant for studies examining feedback-loop integrity and physiological GH pulsatility.
What purity level is this sermorelin?
≥99% purity confirmed via HPLC analysis. Each batch includes third-party testing documentation.
How should sermorelin be stored for research use?
Store lyophilized at -20°C. After reconstitution with bacteriostatic water, refrigerate at 2-8°C and use within 21 days.
What is the molecular weight of sermorelin?
3,357.9 Daltons. The peptide consists of 29 amino acid residues corresponding to the biologically active N-terminal segment of native GHRH(1-44).
Can sermorelin be used alongside other research peptides?
Yes. In published research protocols, GHRH analogs have been studied in combination with GHRP-class peptides to examine synergistic GH release. Researchers also pair sermorelin with other peptides depending on the axis being investigated.
What is the half-life of sermorelin in research models?
Approximately 10-20 minutes in circulation, which is why pulsatile administration protocols are standard in most published research.
Where can I buy sermorelin for research?
PreWorkout Formula supplies 99%+ purity sermorelin with HPLC verification and fast shipping. All products are sold strictly for research purposes.
This product is intended for laboratory and research use only. Not for human consumption. By purchasing, you agree to use this product solely for legitimate research purposes.
