CJC-1295
$44.99
CJC-1295 (with DAC) — a long-acting GHRH analog with a 6-8 day half-life, shown to sustain GH and IGF-1 elevation for up to 14 days in published research. 99%+ purity, HPLC verified.
Description
CJC-1295: The Synthetic GHRH Analog That Changed Growth Hormone Research
Back in 2005, a team at ConjuChem Biotechnologies did something nobody expected. They took a 29-amino-acid growth hormone releasing hormone (GHRH) analog and attached a Drug Affinity Complex (DAC) — a maleimidopropionic acid linker that binds irreversibly to serum albumin. The result? A peptide with a half-life of roughly 6-8 days, compared to the 7-minute half-life of native GHRH. Published findings from Teichman et al. (Journal of Clinical Endocrinology & Metabolism, 2006) showed sustained GH elevation for up to 14 days after a single subcutaneous administration.
That’s not a typo. Fourteen days of measurable GH elevation from one dose.
Mechanism of Action — How CJC-1295 Actually Works
CJC-1295 binds to the GHRH receptor (GHRH-R) on anterior pituitary somatotroph cells. But here’s where it gets interesting — it doesn’t just blast GH release like exogenous growth hormone would. It preserves the natural pulsatile secretion pattern. The hypothalamic-pituitary feedback loop stays intact.
Key distinction: CJC-1295 amplifies existing GH pulses rather than creating artificial spikes. Somatostatin still provides its inhibitory rhythm. You get elevated GH and IGF-1 without the flat, supraphysiological plateaus that come with direct GH administration.
The DAC modification is what separates CJC-1295 from its non-DAC counterpart (mod-GRF 1-29). Without DAC, the peptide clears in under 30 minutes. With DAC, albumin binding creates a circulating reservoir that feeds the GHRH receptor continuously.
Research Applications and Published Data
| Parameter | Detail |
|---|---|
| Molecular Formula | C152H252N44O42 |
| Molecular Weight | 3367.9 g/mol |
| Sequence | Modified GHRH (1-29) with DAC |
| Half-Life | ~6-8 days (with DAC) |
| Purity (HPLC) | ≥99% |
| Storage | Lyophilized, -20°C recommended |
| Reconstitution | Bacteriostatic water |
In the Teichman 2006 study, healthy adults receiving 30-60 mcg/kg doses showed mean GH increases of 2-10 fold above baseline. IGF-1 levels rose 1.5-3x over a two-week observation period. No significant adverse events were reported at any dose tested.
A separate study by Ionescu and Bhatt (2006, Growth Hormone & IGF Research) examined repeated weekly dosing and found consistent IGF-1 elevation without tachyphylaxis — the receptor didn’t desensitize. That’s a meaningful finding for longitudinal research protocols.
Why Researchers Pair CJC-1295 With Secretagogues
GHRH analogs and GH secretagogues (GHS) hit different receptors. CJC-1295 activates GHRH-R. Peptides like Ipamorelin or GHRP-6 activate the ghrelin receptor (GHS-R1a). When both receptor pathways fire simultaneously, the GH response isn’t additive — it’s synergistic. Published data from Bowers (1998, Journal of Pediatric Endocrinology) demonstrated GH output 2-3x higher than either pathway alone.
That’s exactly why the CJC-1295 / Ipamorelin blend has become one of the most studied combinations in GH-axis research.
What Ships to Your Lab
Each vial contains lyophilized CJC-1295 (with DAC) at 99%+ purity verified by third-party HPLC and mass spectrometry. Sealed under nitrogen, shipped with desiccant. Certificate of analysis included.
Price: $44.99 per vial
Frequently Asked Questions
What is CJC-1295 used for in research?
CJC-1295 is used to study sustained growth hormone releasing hormone receptor activation, IGF-1 modulation, and the effects of prolonged GH-axis stimulation in controlled laboratory settings.
What is the difference between CJC-1295 with DAC and without DAC?
The DAC (Drug Affinity Complex) binds to serum albumin and extends half-life from ~30 minutes to 6-8 days. Without DAC (often called mod-GRF 1-29), the peptide requires much more frequent administration in research protocols.
How should CJC-1295 be stored?
Lyophilized CJC-1295 should be stored at -20°C. Once reconstituted with bacteriostatic water, store at 2-8°C and use within 4 weeks for optimal stability.
What purity is CJC-1295 from PreWorkout Formula?
Every batch is third-party tested at 99%+ purity via HPLC analysis. Mass spectrometry confirms molecular identity. COA available on request.
Can CJC-1295 be combined with other peptides in research?
Yes. CJC-1295 is frequently studied alongside GH secretagogues like Ipamorelin and GHRP-6 due to the synergistic GH response documented when GHRH-R and GHS-R1a are co-activated.
How long does CJC-1295 stay active in research models?
Published pharmacokinetic data shows measurable activity for 6-14 days after a single administration, depending on dose and model organism.
Where can I buy CJC-1295 for research?
PreWorkout Formula supplies CJC-1295 at 99%+ purity with fast shipping. Browse all available compounds on our peptides for sale page.
What is the molecular weight of CJC-1295?
CJC-1295 (with DAC) has a molecular weight of approximately 3367.9 g/mol.
Related Research Peptides
- Ipamorelin — Selective GHS-R1a agonist, commonly studied alongside CJC-1295
- CJC-1295 / Ipamorelin Blend — Pre-combined for synergistic GH-axis research
- GHRP-6 — Potent ghrelin mimetic with strong GH secretagogue activity
- IGF-1 LR3 — Long-acting insulin-like growth factor for downstream pathway research
- BPC-157 — Gastric pentadecapeptide studied for tissue repair mechanisms
- TB-500 — Thymosin beta-4 fragment researched for cellular migration and repair
This product is intended for laboratory and research use only. Not for human consumption. All buyers must be qualified researchers or institutions. By purchasing, you agree to use this product solely for legitimate research purposes.